Current Issue : April-June Volume : 2025 Issue Number : 2 Articles : 5 Articles
Two polysaccharide-based chiral stationary phase columns were evaluated to improve the previous partial chiral peak separation to a baseline-resolved separation of the INGREZZA® drug substance and its diastereomers. Moreover, the tailing factor (Tf) variation was studied to investigate chiral column degradation and regeneration and to optimize chiral column performance and efficiency....
Engineering magnetic nanoparticles with tunable structural properties and magnetism is critical to develop desirable magnetic particle imaging (MPI) tracers for biomedical applications. Here we present a new superparamagnetic metal oxide nanoparticle with a controllable chemical composition and magnetism for imaging tumor xenografts in living mice. Superparamagnetic Zn/Fe mixed metal oxide (ZnFe-MMO) nanoparticles are fabricated via a facile one-pot co-precipitation method in water followed by thermal decomposition with tunable Zn/Fe ratios and at various calcination temperatures. This work, for the first time, presented LDH-derived metal oxides for an MPI application. The metal composition is tunable to present an optimized MPI performance. The analytical results demonstrate that ZnFe-MMO nanoparticles at the designed molar ratio of Zn/Fe = 2:1 after 650 ◦C calcination demonstrate a higher saturation magnetization (MS) value and optimal MPI signal than the samples presented with other conditions. The excellent biocompatibility of ZnFe-MMO is demonstrated in both breast cancer cells and fibroblast cell cultures. In vivo imaging of 4T1 tumor xenografts in mice using ZnFe-MMO as a tracer showed that the mean signal intensity is 1.27-fold higher than the commercial tracer VivoTrax at 72 h post-injection, indicating ZnFe-MMO’s promise for prolonged MPI imaging applications....
Hydrogen (H2) production from renewable biomass resources plays a significant role in solving the shortage of fossil energy; hence, there is an interest in investigating alternative, cleaner processes. This work intends to study the photocatalytic production of hydrogen from D-(+)-Glucose by using different groups of catalysts that have been prepared (M2+ = Zn, Mg and Ni) M2+/Ti4+ Al3+-LDHs (layered double hydroxides). It is then loaded Pd on the catalyst, and the effect of the composite catalyst, layered double hydroxides, is measured. After calcining, the catalyst for the conversion of Layered Double Hydroxides (LDHs) to Layered Double Oxides (LDOs) is used to produce hydrogen gas from glucose. Photocatalytic reforming of glucose-derived compounds is an efficient method for the production of hydrogen. The purpose is to study the effect of metal ions on layered double oxide (LDO) materials by loading Pd and investigate hydrogen production from glucose. The metal cations in the layer were distributed through the preparation of the catalyst process by ion and atom scale between the layers, which were dispersed systematically, as well as the controlled component catalysis. This process shows that ZnTiAl-LDO had the best effect as a catalyst in producing hydrogen compared to NiTiAl-LDO and MgTiAl-LDO....
The present work was the preliminary study of phase diagrams and miscibilities of lowtemperature metallomesogen (MOM) model structures based on rod-like palladium (Pd) alkyl/alkoxyazobenzene metal complexes and their mixtures with commercial liquid crystal materials for potential application. The initial results indicated the accessible temperature range and mesgenic miscibility between parent ligand, MOMs and commercial liquid crystal mixtures. The eutectic ligand/MOM composition with other MOMs and commercial nematic liquid crystal materials exhibited complete mesogenic miscibility and wide low-temperature mesogenic stability for eventual utilization in commercial liquid crystal devices....
Nano alumina was synthesised using precursors from pre-heated kaolinitic clay at 600˚C, 700˚C, and 800˚C following by a bottom-up sol gel method that led to Al(OH)3. The latter was subsequently calcinated at 900˚C to form γ - nano alumina (γ-Al2O3). The final products were characterised using X-ray Diffraction (XRD), Fourier transformed infrared Spectroscopy (FTIR), Scanning electron Microscopy (SEM) coupled with Energy dispersive X-ray analysis (EDX) as well as Brunauer-Emmett-Teller (BET) for specific surface area measurement. The γ-nano alumina confirmed by X-ray patterns and infrared spectroscopy was found to be in a poorly crystalized form with 6.8 nm as crystallite size. The specific surface area and the synthesis yield varied with the temperature of pre-heating kaolinitic clay. The best process yield, 17.88%, and specific surface area of 146.78 m2/g, was obtained with 700˚C as the best preheating temperature of the precursor. Due to the characteristics of the product obtained, they could be very interesting in many applications such as adsorption given their high specific area and nanoscale structure....
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